Tổng hợp về ASPIRIN

AspirinAspirin chứ không phải vitamin E ngăn ngừa cơn đau tim

Nghiên cứu mới đây của các nhà khoa học Italia cho thấy Aspirin làm giảm nguy cơ chết vì bệnh tim cũng như nguy cơ bị cơn đau tim đột quỵ đau ngực và các vấn đề tim mạch khác. Trong khi đó vai trò của vitamin E trong các bệnh lý này còn rất mờ nhạt.

Tác dụng rõ rệt của Aspirin

Nghiên cứu được thực hiện trên 4.500 nam giới và phụ nữ từ 50 tuổi trở lên và có ít nhất 1 yếu tố nguy cơ đối với bệnh tim mạch như: cao huyết áp đái đường hay béo phì. Họ được chỉ định: uống cả 2 thuốc Aspirin và vitamin E chỉ uống Aspirin chỉ uống vitamin E hoặc không uống thuốc nào. Thời gian theo dõi trung bình là 3 6 năm. Nghiên cứu đã kết thúc trước thời hạn vì hiệu quả của Aspirin quá rõ ràng: với liều lượng 1 viên/ngày thuốc làm giảm nguy cơ chết vì cơn đau tim hay đột quỵ trong 50 % trường hợp.

Cùng với những nghiên cứu trước đây kết luận này sẽ giúp các bác sĩ "tự tin" hơn khi khuyên bệnh nhân sử dụng Aspirin liều thấp để phòng cơn đau tim đầu tiên và các cơn đột quỵ.

Nghi ngờ về tác dụng của vitamin E

Nghiên cứu trước đây về thuốc này đưa lại những kết quả đối lập. Liều trung bình dùng hàng ngày chỉ có hiệu quả giảm nguy cơ mắc bệnh động mạch ở chân. Là một chất chống ô xy hóa nó giúp trung hoà các gốc tự do có khả năng huỷ hoại tế bào lưu hành trong máu. Một số nghiên cứu cho rằng điều này sẽ giúp bảo vệ con người khỏi bệnh tim mạch và đột quỵ. Rõ ràng là cần có thêm nhiều nghiên cứu khác để có thể hiểu rõ vai trò của vitamin E.

Aspirin kéo dài tuổi thọ của các cơ quan cấy ghép

Đó là do aspirin có tác dụng chống sự viêm nhiễm - điều thường xảy ra với các bộ phận cấy ghép một thời gian dài sau khi được phẫu thuật làm giảm tuổi thọ của chúng. Kết luận này được tiến sĩ Zac Varghesse thuộc Viện Hoàng gia London (Anh) đưa ra.

Ông Varghesse cho biết dù những ca phẫu thuật có thành công đến 90-99% thì sau 10 năm khoảng 60% các cơ quan cấy ghép sẽ bị viêm nhiễm. Các tác nhân gây viêm nhiễm làm tích lũy một lượng lớn chất lipid trong tế bào. Điều này gây ra hiện tượng xơ hóa hoặc làm tổn thương bộ phận được cấy ghép ở cơ thể người   bệnh. Những triệu chứng này thường rất khó chẩn đoán và xảy ra sau một thời gian dài.

Aspirin giúp phòng bệnh ung thư tụy tạng

Theo một nghiên cứu của Đại học Minnessota (Mỹ) aspirin có thể giúp giảm nguy cơ ung thư tụy tạng ở phụ nữ. Ở những người thường dùng thuốc này nguy cơ ung thư thấp hơn 43% so với những người không dùng.

Trong vòng 7 năm (từ năm 1992 đến 1999) các nhà khoa học đã theo dõi việc sử dụng aspirin hoặc các sản phẩm chứa aspirin ở hàng chục nghìn phụ nữ. Những người này được chia thành 4 nhóm: không bao giờ dùng dùng 1 lần/tuần 2-5 lần/tuần và 6 lần trở lên/tuần. Kết quả cho thấy những phụ nữ nào càng dùng aspirin thường xuyên thì nguy cơ ung thư tụy tạng càng thấp.

Các nghiên cứu trước đây cho thấy aspirin cũng có tác dụng ngăn ngừa đối với nhiều dạng ung thư khác như ung thư đại tràng phổi tuyến tiền liệt...

Aspirin có khả năng giảm ung thư và mất trí nhớ

Tại hội nghị về việc sử dụng thuốc Aspirin để ngăn ngừa ung thư được tổ chức tại Luân Đôn (Anh) ngày 10-11 các chuyên gia y tế đã đưa ra những bằng chứng cho thấy loại thuốc này có tác dụng giảm nguy cơ đau tim và đột quị phòng chống nghẽn mạch ung thư vú ung thư tuyến tiền liệt hoặc ung thư ruột kết.

Các nhà khoa học đã nghiên cứu 1.000 người có biểu hiện ung thư ruột kết và kết quả cho thấy những người uống Aspirrin có nguy cơ phát bệnh giảm 19%.

Một nghiên cứu khác đối với 80.000 phụ nữ cũng cho thấy những người thường xuyên sử dụng Aspirin thì nguy cơ ung thư vú giảm 28% so với những người không dùng thuốc.

Ngoài ra các nhà khoa học còn tìm được bằng chứng cho thấy Aspirin có thể ngăn chặn chứng mất trí nhớ do lão suy thường xảy ra ở người trên 70 tuổi.

Với kết quả nghiên cứu khả quan nói trên các bác sĩ ở Anh tin rằng trong vòng 10 năm tới tất cả những người trên 60 tuổi sẽ được khuyên uống Aspirin thường xuyên để phòng chống ung thư và mất trí nhớ. Tuy nhiên kết qủa này vẫn cần được nghiên cứu thêm để phát hiện phản ứng phụ.

Aspirin dành cho người khỏe mạnh

Cuộc nghiên cứu mới do các nhà khoa học thuộc Viện Tim mạch của Trung tâm Y khoa Mount Sinai và Viện Tim Miami thực hiện tập trung phân tích dữ liệu liên quan đến 55.580 bệnh nhân tim mạch nhận thấy aspirin có thể giảm 32% nguy cơ đột quị lần đầu tiên giảm được cùng lúc 15% các nguy cơ đột quị đau tim và các vấn đề về mạch máu.

Bác sĩ Charles Hennekens tác giả cuộc nghiên cứu nói nam giới trên 40 tuổi và nữ giới trên 50 tuổi nên tham khảo ý kiến của bác sĩ xem có cần uống aspirin hằng ngày như một biện pháp phòng ngừa hay không.

Ngoài ra Hội Tim Hoa Kỳ cũng khuyên nên dùng aspirin đối với những người đã từng bị đột quị hay viêm họng thiếu máu cục bộ do cục máu đông hoặc đột quị nhất thời do thiếu máu.

Aspirin liều thấp cũng có thể gây biến chứng

Các nhà nghiên cứu thuộc Đại học Oxford (Anh) đã đưa ra kết luận: Khoảng 1% bệnh nhân uống Aspirin trong thời gian 28 tháng bị chảy máu dạ dày. Nhận xét này được đúc kết từ 24 nghiên cứu thực hiện trên 66.000 người bệnh dùng Aspirin liều thấp.

Aspirin thường được sử dụng rộng rãi để phòng bệnh tim. Trước đây người ta nghĩ rằng việc dùng Aspirin hàng ngày với liều thấp ít có nguy cơ gây chảy máy dạ dày như dùng liều cao. Kết luận mới này khiến các bác sĩ và bệnh nhân phải cân nhắc nhiều hơn khi quyết định chọn liệu pháp Aspirin.

Aspirin không phải lúc nào cũng tốt cho tim mạch

Một nghiên cứu mới đây cho thấy 75% bệnh nhân tim mạch có biểu hiện kháng aspirin. Điều đó không chỉ làm giảm hiệu lực của thuốc mà còn tăng nguy cơ tử vong của bệnh nhân.

Để giúp ngăn chặn các cơn đau tim các bác sĩ thường cho bệnh nhân dùng aspirin vì thuốc này có thể chặn đứng việc hình thành thromboxane A2 một hóa chất tạo ra tiểu cầu gây đông máu (nguyên nhân dẫn đến các cơn đau tim). Tuy nhiên theo nghiên cứu nói trên việc sử dụng aspirin không đủ ngăn cản sự hình thành thromboxane ở những người kháng thuốc. Nguy cơ tử vong vì đau tim ở họ cao hơn 3 5 lần so với những người đáp ứng tốt với aspirin.

Để biết bệnh nhân có kháng aspirin hay không các bác sĩ chỉ cần thực hiện một thử nghiệm nước tiểu đơn giản. Nếu kháng thuốc bệnh nhân sẽ được điều trị thêm bằng thuốc chống đông máu.

Anh cấm trẻ dưới 16 tuổi dùng aspirin

Việc sử dụng aspirin ở đối tượng nói trên dẫn tới một bệnh nguy hiểm cho não và gan mang tên Hội chứng Reye. Nguy cơ này tuy nhỏ (1/1 triệu) nhưng có thể dẫn tới tử vong. Tuyên bố được Cơ quan Quản lý Dược phẩm của Anh (MCA) đưa ra hôm qua.

Khoảng 140 sản phẩm do 50 công ty sản xuất sẽ chịu ảnh hưởng của khuyến cáo nói trên. MCA cũng đang xem xét khả năng áp dụng lệnh cấm cho tất cả các sản phẩm chứa thuốc giảm đau aspirin.

Kể từ năm 1986 Anh đã cấm sử dụng aspirin cho trẻ dưới 12 tuổi vì nguy cơ gây hội chứng Reye với biểu hiện phù não và tổn thương gan. Nhờ đó tỷ lệ mắc bệnh đã giảm. Hồi đầu năm nay MCA cũng khuyên trẻ dưới 16 tuổi không dùng aspirin trong giai đoạn bị sốt. Tuy nhiên khuyến cáo này quá phức tạp đẩy gánh nặng lên bọn trẻ và cha mẹ vì họ phải tự quyết định khi nào không được dùng thuốc. Khuyến cáo mới giúp đơn giản hóa vấn đề.

Hội chứng Reye thường xuất hiện ở trẻ dưới 5 tuổi nhưng có thể gặp ở trẻ lớn hơn với các biểu hiện: nôn nhiều lơ mơ hoặc mất ý thức sau khi nhiễm virus. Hiện vẫn chưa có cách điều trị bệnh nhân có thể tử vong trong vòng vài ngày hoặc trở thành tàn phế suốt đời. Nguyên nhân của hội chứng Reye còn chưa được làm rõ nhưng người ta cho rằng sử dụng aspirin khi trẻ đang bị sốt có thể là yếu tố góp phần dẫn tới bệnh. Cũng không rõ tại sao chỉ trẻ em bị ảnh hưởng còn người lớn thì không.

Trẻ dưới 16 tuổi có thể cần dùng aspirin để điều trị một số bệnh như viêm khớp tuổi thiếu niên bệnh Kawasaki viêm mạch máu...Nạn nhân cuối cùng của hội chứng Reye ở Anh là một em gái 13 tuổi tử vong hồi tháng tư và nghi có dùng aspirin.
                                                                         Tổng hợp từ ykhoanet.com
Mời bạn xem bài chi tiết về Aspirin: http://vi.wikipedia.org/wiki/Aspirin
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